John Cook sums it up well:
It's impossible to overstate the shock to the system a realization like this has to someone in McCain's position. For the first time in history, people aren't being given the opportunity to be born the son of an admiral who commanded the Pacific fleet or the daughter of one of the richest men in Arizona. Let that sink in for a moment. ("I'm the daughter of one of the most long-standing senators in politics and I have been given every opportunity that anyone could possibly dream of" should be tattooed across her lower back. In fact it's the perfect new name for her Daily Beast column!)